Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans

To determine how to set optimal oral L-serine (serine) dose levels for a clinical trial, existing literature was surveyed.Data sufficient to set the dose was inadequate, and so an (n = 10) phase I-A calibration trial was performed, administering serine with and PVC Shade Mesh without other oral agents.We analyzed the trial and the literature data u

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Fragile X-Associated Tremor Ataxia Syndrome: The Expanding Clinical Picture, Pathophysiology, Epidemiology, and Update on Treatment

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive degenerative movement disorder characterized by kinetic tremor, cerebellar gait ataxia, parkinsonism, and cognitive decline.This disorder occurs in both males and females, frequently in families with children who have fragile X syndrome.The clinical features of this disorder, both

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Estimates of Daily Evapotranspiration in the Source Region of the Yellow River Combining Visible/Near-Infrared and Microwave Remote Sensing

The spatial variation of surface net radiation, soil heat flux, sensible heat flux, and latent heat flux at different times of the day over the northern Tibetan Plateau were estimated using the Surface Energy Balance System algorithm, data from the FY-2G geostationary meteorological satellite, and microwave data from the FY-3C polar-orbiting meteor

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Utilizing integrated bioinformatics and machine learning approaches to elucidate biomarkers linking sepsis to fatty acid metabolism-associated genes

Abstract Sepsis, characterized as a systemic inflammatory response triggered by the invasion of pathogens, represents a continuum that may escalate from mild systemic infection to severe sepsis, potentially resulting in septic shock and multiple organ dysfunction syndrome.Advancements in lipidomics and metabolomics have unveiled the complex role Cl

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The Contribution of Interfaith Dialogue toward a Culture of Peace

Dialogue among the adherents of the major world religions has always taken place, especially, but not only, among the Abrahamic faiths: Judaism, Christianity and Islam.Excellent examples of this may be Clothing / Promotional found in the midst of shared histories where we are more often presented with a record of conflicts.The high points must be t

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